Web15 Dec 2011 · Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal cancers (CRC), its expression is sustained or even slightly increased despite frequent loss of … Web18 May 2024 · Though not directly suggesting a specific role of platelet-stored THBS1 in PCa progression, the results of our clinical studies measuring THBS1 in the serum of patients belonging to two different cohorts validate the value of serum THBS1 in aiding the diagnosis of PCa [3, 4, 23, 24]. Therefore, our CE-marked Proclarix test was developed to …
THBS1 protein (human) - STRING interaction network
Web28 Aug 2008 · Thrombospondin 1 (TSP1) is a secreted glycoprotein that is predominantly stored in platelets but also secreted at low levels by many cell types, including monocytes and macrophages. ... THBS1-transfected cells. MDA-MB-435 cells transfected with the THBS1 expression plasmid (clone TH26, ... Web18 Jun 2024 · Other markers in this analysis are CCL8, folate receptor 2 (Folr2), platelet factor 4 (Pf4), and carbonyl reductase (Cbr2). Interestingly, myocardial tissue–resident macrophages also expressed high levels of Lyve1 and Folr2 . ... Thbs1, a large (∼ 450 kD) glycoprotein, is a key angiogenic checkpoint . It plays a major role in both ... aten ka7176
7057 - Gene ResultTHBS1 thrombospondin 1 [ (human)]
Web10 Jun 2008 · It is a multifunctional protein that contains binding sites for thrombin, fibrinogen, heparin, fibronectin, plasminogen, plasminogen activator, collagen, laminin, etc. It functions in many cell adhesion and migration events, including platelet aggregation. It also influences granule cell migration during histogenesis of the cerebellar cortex. Web27 Jul 2024 · Although the primary source (s) of circulating TSP1 under basal and disease conditions have not been confirmed, it should be pointed out that platelet alpha granules contain large amounts of preformed TSP1 ( 68) that is released with platelet activation, a common event during blood sampling. http://genome-asia.ucsc.edu/cgi-bin/hgGene?hgsid=792135305_atI8k2tPzYndFDHK4CGvv50v9Pb5&hgg_section_method_close=1 aten ka7188