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Thbs1 platelet

Web15 Dec 2011 · Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal cancers (CRC), its expression is sustained or even slightly increased despite frequent loss of … Web18 May 2024 · Though not directly suggesting a specific role of platelet-stored THBS1 in PCa progression, the results of our clinical studies measuring THBS1 in the serum of patients belonging to two different cohorts validate the value of serum THBS1 in aiding the diagnosis of PCa [3, 4, 23, 24]. Therefore, our CE-marked Proclarix test was developed to …

THBS1 protein (human) - STRING interaction network

Web28 Aug 2008 · Thrombospondin 1 (TSP1) is a secreted glycoprotein that is predominantly stored in platelets but also secreted at low levels by many cell types, including monocytes and macrophages. ... THBS1-transfected cells. MDA-MB-435 cells transfected with the THBS1 expression plasmid (clone TH26, ... Web18 Jun 2024 · Other markers in this analysis are CCL8, folate receptor 2 (Folr2), platelet factor 4 (Pf4), and carbonyl reductase (Cbr2). Interestingly, myocardial tissue–resident macrophages also expressed high levels of Lyve1 and Folr2 . ... Thbs1, a large (∼ 450 kD) glycoprotein, is a key angiogenic checkpoint . It plays a major role in both ... aten ka7176 https://op-fl.net

7057 - Gene ResultTHBS1 thrombospondin 1 [ (human)]

Web10 Jun 2008 · It is a multifunctional protein that contains binding sites for thrombin, fibrinogen, heparin, fibronectin, plasminogen, plasminogen activator, collagen, laminin, etc. It functions in many cell adhesion and migration events, including platelet aggregation. It also influences granule cell migration during histogenesis of the cerebellar cortex. Web27 Jul 2024 · Although the primary source (s) of circulating TSP1 under basal and disease conditions have not been confirmed, it should be pointed out that platelet alpha granules contain large amounts of preformed TSP1 ( 68) that is released with platelet activation, a common event during blood sampling. http://genome-asia.ucsc.edu/cgi-bin/hgGene?hgsid=792135305_atI8k2tPzYndFDHK4CGvv50v9Pb5&hgg_section_method_close=1 aten ka7188

Human Gene THBS1 (ENST00000260356.6) from GENCODE V43

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Thbs1 platelet

Thrombospondin 1 Promotes Tumor Macrophage Recruitment …

Web4 Apr 2024 · This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V … Web22 Apr 2024 · In the current study, we identified Thbs1 as an extracellular regulator of YAP, which is induced by mechanical stress and acts through FAs independent of actin remodeling. Mechanistically, Thbs1 binds integrin αvβ1 and strengthens FAs, aiding in translocation of YAP to the nucleus.

Thbs1 platelet

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Web27 Sep 2024 · In addition, we successfully validated up-regulated proteins of platelet factor 4 variant 1 (PF4V1), thrombospondin-1 (THBS1), platelet basic protein (PBP) and fructose-bisphosphate aldolase A (ALDOA) in another group, which could make discrimination between AF patients and controls. Conclusions WebDescription: Homo sapiens thrombospondin 1 (THBS1), mRNA. (from RefSeq NM_003246) ... This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000260356.6 Gencode Gene: ENSG00000137801.11 Transcript (Including UTRs)

Web5 Nov 2024 · In addition, THBS1 was f ound to be involved in platelet degr anulation. Considering the de granulation will be exagger ated the platelet re sponse[32], targe ting … Web10 Jun 2005 · Thrombospondin-1 (THBS1) is a large extracellular matrix glycoprotein that affects vasculature systems such as platelet activation, angiogenesis, and wound healing. …

WebThrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells. Web8 Mar 2024 · THBS1 was first discovered in platelets but has now been shown to have an important role in cancer development 8, 9. ... b qPCR of THBS1 transcript from the core or …

Web31 Jan 2024 · Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1’s diverse functions are attributed to interactions between the modular domains of THBS1 with an array of proteins found in the extracellular matrix.

WebIntroduction. As the sixth most commonly occurred cancer all over the world, head and neck squamous cell carcinoma (HNSCC) is responsible for around half a million deaths annually, and remains to be a major health issue globally. 1 In the United States, HNSCC accounts for approximately 4% of all cancers. 2 Classical risk factors of HNSCC are smoking and … aten komputerWebDescription: Homo sapiens histidine rich glycoprotein (HRG), mRNA. (from RefSeq NM_000412) RefSeq Summary (NM_000412): This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal … aten us3342 manualWeb1 Jan 2024 · Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and aten padWeb9 Mar 2024 · Also known as TSP; THBS; TSP1; TSP-1; THBS-1 Summary The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein … aten uh3238WebHuman Thrombospondin-1 Quantikine ELISA Kit Summary Assay Type Solid Phase Sandwich ELISA Format 96-well strip plate Assay Length 4.5 hours Sample Type & Volume Required Per Well Cell Culture Supernates (25 uL), Serum (10 uL), Platelet-poor EDTA Plasma (25 uL), Platelet-poor Heparin Plasma (25 uL), Saliva (50 uL), Human Milk (50 uL) … aten ueh4102WebTHBS1 is infrequently mutated in most cancers, but its expression is positively regulated by several tumor suppressor genes and negatively regulated by activated oncogenes and … aten restaurangerWebProstate cancer is the most common malignant tumour in men. Improved testing for diagnosis, risk prediction, and response to treatment would improve care. Here, we identified a proteomic signature of prostate cancer in peripheral blood using data-independent acquisition mass spectrometry combined with machine learning. A highly predictive … aten uh7230