Web1 day ago · Targeting oncofusion proteins is an attractive approach for cancer treatment. First, fusion proteins are specifically expressed in cancer cells rather than in normal cells. Accordingly, the specific targeting of fusion proteins potentially offers limited toxicity. Furthermore, fusion proteins may be the sole driver of some cancers, making them ... WebDec 4, 2011 · Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular proteins involving ubiquitin. The mammalian cullin …

AmiGO 2: Term Details for "protein binding" (GO:0005515)

WebDec 8, 2024 · Summary Predicted to enable cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination; and ubiquitin-dependent protein catabolic … WebApr 12, 2024 · This variant Spry2 behavior, linked to specific stimuli or cell types, seems to depend on its binding to protein phosphatase 2 A (PP2A) and the resulting dephosphorylation of certain residues of ... iowa state fraternities

DCUN1D5 Gene - GeneCards DCNL5 Protein DCNL5 Antibody

WebGene ID: 31014, updated on 24-Nov-2024 Summary Enables cullin family protein binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. WebMembers of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that … WebThe evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3 ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of … iowa state fraternity gpa